Recombinant Mouse CTLA-4/CD152 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ala37-Asp161) of mouse CTLA-4/CD152 (Accession #P09793) fused with an Fc tag at the C-terminus.
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Withinthe ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cellcostimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells.CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4is also found inregulatory T cells and may play an important role in their functions. T cell activation through theT cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have beenassociated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac diseasetype3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
|Routing||Fc tag at the C-terminus|
|Purity||> 95% by SDS-PAGE.|
|Endotoxin||< 1 EU/μg of the protein by LAL method.|
|Formulation||Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.|
|Reconstitution||Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.|
|Storage Conditions||Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.|
$510.00 – $810.00