Recombinant Mouse CD28/TP44 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Asn20-Lys149) of mouse CD28/TP44 (Accession #P31041) fused with an Fc, 6×His tag at the C-terminus.
T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteinsexpressed on T cells that provide co-stimulatory signals, which are required for their activation. It is thereceptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulatedin antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is theonly B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cellproliferation and cytokine production and promotion of T-cell survival.
|Routing||Fc, 6×His tag at the C-terminus|
|Purity||> 95% by SDS-PAGE.|
|Endotoxin||< 1 EU/μg of the protein by LAL method.|
|Formulation||Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.|
|Reconstitution||Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.|
|Storage Conditions||Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.|
$340.00 – $470.00