Recombinant Human CCL18/PARC Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala21-Ala89) of human CCL18/PARC (Accession #P55774) fused with an initial Met at the N-terminus and a 6×His tag at the N-terminus.
C-C Motif Chemokine 18 (CCL18) is secreted protein that belongs to the intercrine beta (chemokine CC) family.CCL18 is expressed at high levels in the lung, lymph nodes, placenta, bone marrow, and dendritic cells. CCL18 isa chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 is a novel CCchemokine that is highly homologous to MIP-1 alpha. CCL18 may be involved in B-cell migration into B-cellfollicles in lymph nodes. CCL18 attracts naive T-lymphocytes toward dendritic cells and activated macrophagesin lymph nodes. It has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role inboth humoral and cell-mediated immunity responses.
|Routing||6×His tag at the N-terminus|
|Purity||> 95% by SDS-PAGE.|
|Endotoxin||< 1 EU/μg of the protein by LAL method.|
|Formulation||Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.|
|Reconstitution||Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.|
|Storage Conditions||Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.|
$1,428.00 – $2,040.00