ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
|Synonyms||ACLY; ACL; ATPCL; CLATP; ATP citrate lyase|
|Immunogen||A synthetic phosphorylated peptide around S455 of human ACLY (NP_001087.2).|
|Purification Method||Affinity purification|
|Buffer||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
WB 1:500 – 1:2000
|Storage Conditions||Store at -20°C. Avoid freeze / thaw cycles.|
$300.00 – $480.00