TIM-3 belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. TIM-3 is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
|Lot:||Please refer to product vial|
|Immunogen:||Recombinant protein of human TIM-3|
|Synonyms:||HAVCR2; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2|
|Calculated MW:||33 kDa|
|Observed MW:||Refer to figure|
|Species Reactivity:||Human, Mouse|
WB: 1:500 – 1:2000
|Purification Method:||Affinity purified|
|Buffer:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Storage Conditions:||Store at -20°C. Avoid freeze / thaw cycles.|
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.