OX40 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
|Lot:||Please refer to product vial|
|Immunogen:||Recombinant protein of human OX40|
|Synonyms:||TNFRSF4; OX40; ACT35; CD134; IMD16; TXGP1L;|
|Calculated MW:||29 kDa|
|Observed MW:||Refer to figure|
|Species Reactivity:||Human, Mouse, Rat|
WB: 1:500 – 1:2000
|Purification Method:||Affinity purified|
|Buffer:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Storage Conditions:||Store at -20°C. Avoid freeze / thaw cycles.|
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.