Human CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
This CTLA-4 antibody was developed from mouse immunization, and expressed in suspension culture of mouse hybridoma clone CB17.
|Lot:||Please refer to product vial|
|Immunogen:||Human CTLA-4, extracellular domain|
|Synonyms:||CTLA4; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; ICOS; IDDM12|
|Applications:||FACS, ELISA, Functional assays|
ELISA: 0.2-1.0 ug/mL
FACS: 1-5 ug/mL
Functional assays: 1-10 ug/mL
|QC:||Endotoxin level: <2 EU/mg by the LAL method Purity: >95% by HPLC and SDS-PAGE|
|Production Method:||Expressed from mouse hybridoma clone CB17|
|Purification Method:||Affinity purified|
|Buffer:||PBS, pH 7.4|
|Storage Conditions:||Store at -20°C. Avoid freeze / thaw cycles.Stable for 12 months from date of purchase when stored as recommended.|
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.