CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. It is expressed on the cell surface as disulfide-linked homodimer or as monomer.
CD28 is the only B7 receptor constitutively expressed on naive T cells. Stimulation through CD28 in addition to the TCR can provide a potent co-stimulatory signal to T cells for the production of various interleukins (IL-2 and IL-6 in particular). CD28 possesses an intracellular domain with several residues that are critical for its effective signalling.
Anti-Mouse CD28 recognizes the CD28 co-stimulatory receptor, a ligand of CD80 (B7-1) and CD86 (B7-2).
|Host species:||Syrian Hamster|
|Ig Subclass:||Syrian Hamster IgG|
|Alternate Names:||MGC138290, Tp44|
|Reported Applications:||Immunohistochemistry (Frozen), FLOW Cytometry, Immunoprecipitation, Blocking, Functional Assay|
|Purification Method:||Affinity Purified|
|Buffer:||0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.|
|Purity:||>95% by SDS-PAGE and HPLC|
|Endotoxin Level:||<0.75 EU/mg as determined by the LAL method|
|Concentration:||1.0 - 5.0 mg/ml|
|Additional Testing:||This antibody has been certified by PCR to be free of relevant rodent pathogens.|
|Storage Conditions:||Store at 2-8°C. For long term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.|
$198.00 – $2,220.00