PD-L1, also known as CD274, is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. This PD-L1 antibody was developed from mouse immunization, and expressed in adherent culture of mouse hybridoma clone CB34.
|Lot:||Please refer to product vial|
|Immunogen:||Human PD-L1, ECD domain|
|Synonyms:||CD274; B7-H; B7H1; MGC142294; MGC142296; PDCD1L1; PDCD1LG1; PDL1|
|Applications:||ELISA, FACS, WB|
ELISA: 0.2-1.0 ug/mL, FACS: 1-5 ug/mL, WB: 1-5 ug/mL
|QC:||Endotoxin level: <2 EU/mg by the LAL method, Purity: >90% by SDS-PAGE|
|Production Method:||Expressed from mouse hybridoma clone CB34|
|Purification Method:||Affinity purified|
|Buffer:||PBS, pH 7.4|
|Storage Conditions:||Store at -20°C. Avoid freeze / thaw cycles. Stable for 12 months from date of purchase when stored as recommended.|
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
100 ug - $325.00 – $485.00