PD-1, also known as CD279, is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. This PD-1 antibody was developed from mouse immunization, and expressed in adherent culture of mouse hybridoma clone CB33.
|Lot:||Please refer to product vial|
|Immunogen:||Human PD-1, ECD domain|
|Synonyms:||PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l|
|Applications:||ELISA, FACS, WB|
ELISA: 0.2-1.0 ug/mL, FACS: 1-5 ug/mL, WB: 1-5 ug/mL
|QC:||Endotoxin level: <2 EU/mg by the LAL method, Purity: >90% by SDS-PAGE|
|Production Method:||Expressed from mouse hybridoma clone CB33|
|Purification Method:||Affinity purified|
|Buffer:||PBS, pH 7.4|
|Storage Conditions:||Store at -20°C. Avoid freeze / thaw cycles. Stable for 12 months from date of purchase when stored as recommended.|
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
100 ug - $325.00 – $485.00