Integrin β?7 is a 130 kD highly flexible membrane protein in the Ig superfamily that plays a role in lymphocyte adhesion. This flexibility facilitates a dynamic affinity for ligand via conformational changes. Integrin β7 forms heterodimers with α4 or αE (ITGAE) for structural stability. The α4/β7 heterodimer, also known as LPAM-1, binds to VCAM-1, MAdCAM-1 and fibronectin. The αE/β7 heterodimer interacts with E-Cadherin. Integrin β7 interacts with EED.
|Ig Subclass||Rat IgG2a|
Rat Anti-Mouse Integrin Beta 7 (Integrin β7) (Clone FIB504) recognizes an epitope on Mouse Integrin β7. Integrin β7 heterodimer α4/β7 is expressed on peripheral lymphocytes, thymocytes and bone marrow progenitors. Integrin β7 heterodimer αE/β7 is expressed on intestinal IEL, dendritic epidermal T cells, T regulatory cells, CD8+ T cells in lymph nodes and lamina propria.
|Buffer||0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.|
|Purification Method||Affinity Purified|
|Reporter Molecule||Fluorescein (FITC) is a small fluorescent organic molecule with a molecular weight of 473 daltons with an absorbance maximum of ~492 nm and an emission maximum of ~518 nm.|
|Dilution||Each investigator should determine their own optimal working dilution for specific applications.|
|Storage Conditions||This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.|
|Reported Applications||Flow Cytometry|
|Country of Origin||USA|
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