Interleukin 5 or IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.
|Ig Subclass||Rat IgG2a κ|
Rat Anti-Mouse Interleukin-5 (IL-5) recognizes an epitope on Mouse IL-5.
|Species Reactivity||Mouse, Human|
|Immunogen||Purified Recombinant Mouse IL-5 (>98%)|
|Buffer||0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.|
|Alternate Names||BCDFII, Interleukin-5, IL5, B cell differentiation factor 1, TRF, EDF|
|Purification Method||Affinity Purified|
|Dilution||Each investigator should determine their own optimal working dilution for specific applications.|
|Storage Conditions||This biotinylated antibody is stable e.when stored at 2-8°C. Do not freeze.|
|Reported Applications||ELISA Det, ELISPOT Det, Flow Cytometry|
|Country of Origin||USA|
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE