The CD61 antigen is present on virtually all resting and activated platelets. The antigen is also known to be present on endothelial cells, megakaryocytes and some leukemias of myeloid, erythroid and lymphoid origin.
Anti-CD61 may be used to identify platelets and megakaryocytes. It may also be used in studies to characterize leukemias and in research of cell adhesion molecules.
|Ig Subclass||Mouse IgG1|
Mouse Anti-CD61 (Clone F11) recognizes CD61. Anti-CD61 recognizes the (Mr 110 kDa) common ß-subunit of the gp IIb/IIIa complex and the vitronectin receptor (VNR). The gp IIb antigen and the gp IIIa antigen form the cell adhesion complex (gp IIb/IIIa) which is the receptor on platelets for fibrinogen, von Willebrand factor, fibronectin and vitronectin.
|Immunogen||Purified Recombinant Human CD61 (>98%)|
|Buffer||0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.|
|Alternate Names||Integrin Beta 3|
|Purification Method||Affinity Purified|
|Reporter Molecule||PerCp is a component of the photosynthetic apparatus found in the dinoflagellate Glenodinium. PerCP is a protein complex with a molecular weight of ~35 kDa. Due to its photobleaching characteristics do not use on flow cytometers with high-power lasers.|
|Dilution||Each investigator should determine their own optimal working dilution for specific applications.|
1. Helfrich, M. N. et al. submitted for publication
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE
$150.00 – $250.00