The CD61 antigen is present on virtually all resting and activated platelets. The antigen is also known to be present on endothelial cells, megakaryocytes and some leukemias of myeloid, erythroid and lymphoid origin.
Anti-CD61 may be used to identify platelets and megakaryocytes. It may also be used in studies to characterize leukemias and in research of cell adhesion molecules.
|Ig Subclass||Mouse IgG1|
Mouse Anti-CD61 (Clone F11) recognizes CD61. Anti-CD61 recognizes the (Mr 110 kDa) common ß-subunit of the gp IIb/IIIa complex and the vitronectin receptor (VNR). The gp IIb antigen and the gp IIIa antigen form the cell adhesion complex (gp IIb/IIIa) which is the receptor on platelets for fibrinogen, von Willebrand factor, fibronectin and vitronectin.
|Buffer||0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.|
|Alternate Names||Integrin Beta 3|
|Purification Method||Affinity Purified|
|Reporter Molecule||Allophycocyanin (APC) has a molecular weight of 104 kDa and is purified from green algae. APC is an intensely bright phycobiliprotein with a broad absorption profile that peaks at ~650 nm, and a fluorescence emission maximum of ~660 nm.|
|Dilution||Each investigator should determine their own optimal working dilution for specific applications.|
1. Helfrich, M. N. et al. submitted for publication
FOR RESEARCH USE ONLY. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE
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