CrownBio now offers genomic DNA (gDNA) reference standards, which represent biologically-relevant controls that can be directly incorporated into your sample processing workflows in order to optimize your protocols, evaluate assay sensitivity and specificity, and analyze the impact of workflow changes on downstream analysis. They represent ideal materials for both assay development and routine monitoring of assay performance.

These genomic DNA reference standards are derived from isogenic mutation cell lines with many recurrent pathway-activating mutations in various genes based on data from the Sanger Institute’s COSMIC database.

Name Catalog # Price  

APC E1309fs*4 Genomic DNA

C6146G
Clear

APC R213* Genomic DNA

C6150G
Clear

BRAF V600D Genomic DNA

C6048G
Clear

BRAF V600E Genomic DNA (c.1799_1800TG>AA)

C6046G
Clear

BRAF V600E Genomic DNA (c.1799T>A)

C6047G
Clear

BRAF V600G Genomic DNA

C6050G
Clear

BRAF V600K Genomic DNA

C6044G
Clear

BRAF V600M Genomic DNA

C6049G
Clear

BRAF V600R Genomic DNA

C6045G
Clear

BRCA1 E1161Fs Genomic DNA

C6112G
Clear

BRCA1 E23fs*17 Genomic DNA

C6107G
Clear

BRCA1 Q1756fs*74 Genomic DNA

C6108G
Clear

CTNNB1 S33C Genomic DNA

C6139G
Clear

CTNNB1 S33Y Genomic DNA

C6140G
Clear

CTNNB1 S45del Genomic DNA

C6143G
Clear

EGFR V769_D770insASV Genomic DNA

C6026G
Clear

EGFR c.2310_2311insGGT p.D770_N771insG Genomic DNA

C6027G
Clear

EGFR c.2319_2320insCAC p.H773_V774insH Genomic DNA

C6028G
Clear

EGFR C797S/T790M Genomic DNA (c.2389T>A)

C6177G
Clear

EGFR C797S/T790M Genomic DNA (c.2390G>C)

C6176G
Clear

EGFR E746_A750>IP Genomic DNA

C6024G
Clear

EGFR E746_A750del Genomic DNA (c.2235_2249del15)

C6016G
Clear

EGFR E746_A750del Genomic DNA (c.2236_2250del15)

C6017G
Clear

EGFR E746_S752>A Genomic DNA

C6007G
Clear

EGFR E746_S752>D Genomic DNA

C6005G
Clear

EGFR E746_S752>V Genomic DNA

C6008G
Clear

EGFR E746_T751>A Genomic DNA

C6010G
Clear

EGFR E746_T751>I Genomic DNA

C6014G
Clear

EGFR E746_T751>V Genomic DNA

C6013G
Clear

EGFR E746_T751del Genomic DNA

C6009G
Clear

EGFR G719A Genomic DNA

C6002G
Clear

EGFR G719C Genomic DNA

C6001G
Clear

EGFR G719S Genomic DNA

C6000G
Clear

EGFR K745_E749del Genomic DNA

C6015G
Clear

EGFR L747_A750>P Genomic DNA (c.2238_2248>GC)

C6022G
Clear

EGFR L747_A750>P Genomic DNA (c.2239_2248TTAAGAGAAG>C)

C6021G
Clear

EGFR L747_E749del Genomic DNA

C6023G
Clear

EGFR L747_P753>Q Genomic DNA

C6006G
Clear

EGFR L747_P753>S Genomic DNA

C6004G
Clear

EGFR L747_S752del Genomic DNA

C6003G
Clear

EGFR L747_T751>P Genomic DNA

C6018G
Clear

EGFR L747_T751>Q Genomic DNA

C6020G
Clear

EGFR L747_T751>S Genomic DNA

C6019G
Clear

EGFR L747_T751del Genomic DNA (c.2239_2253del15)

C6011G
Clear

EGFR L747_T751del Genomic DNA (c.2240_2254del15)

C6012G
Clear

EGFR L858R Genomic DNA

C6030G
Clear

EGFR L861Q Genomic DNA

C6031G
Clear

EGFR Q787R Genomic DNA

C6182G
Clear

EGFR S768I Genomic DNA

C6025G
Clear

EGFR T790M Genomic DNA

C6029G
Clear

EGFR V843I Genomic DNA

C6185G
Clear

ESR1 D538G Genomic DNA

C6169G
Clear

ESR1 Y537C Genomic DNA

C6172G
Clear

ESR1 Y537N Genomic DNA

C6171G
Clear

ESR1 Y537S Genomic DNA

C6170G
Clear

FLT3 D835H Genomic DNA

C6154G
Clear

FLT3 I836delI Genomic DNA

C6157G
Clear

HCT116 Genomic DNA (Wild Type)

C6052G-WT
Clear

HRAS G13R Genomic DNA

C6078G
Clear

HRAS Q61K Genomic DNA

C6079G
Clear

HRAS Q61R Genomic DNA

C6080G
Clear

IDH2 R140L Genomic DNA

C6227G
Clear

IDH2 R140Q Genomic DNA

C6225G
Clear

IDH2 R140W Genomic DNA

C6226G
Clear

IDH2 R172G Genomic DNA

C6232G
Clear

IDH2 R172K Genomic DNA

C6228G
Clear

IDH2 R172M Genomic DNA

C6229G
Clear

IDH2 R172S Genomic DNA

C6230G
Clear

IDH2 R172W Genomic DNA

C6231G
Clear

KRAS G12A Genomic DNA

C6037G
Clear

KRAS G12C Genomic DNA

C6032G
Clear

KRAS G12D Genomic DNA

C6036G
Clear

KRAS G12R Genomic DNA

C6034G
Clear

KRAS G12S Genomic DNA

C6033G
Clear

KRAS G12V Genomic DNA

C6035G
Clear

KRAS G13A Genomic DNA

C6042G
Clear

KRAS G13C Genomic DNA

C6038G
Clear

KRAS G13D Genomic DNA

C6041G
Clear

KRAS G13R Genomic DNA

C6040G
Clear

KRAS G13S Genomic DNA

C6039G
Clear

KRAS G13V Genomic DNA

C6043G
Clear

KRAS Q61H Genomic DNA

C6062G
Clear

NRAS E62fs*6 Genomic DNA

C6200G
Clear

NRAS G12C Genomic DNA

C6067G
Clear

NRAS G12D Genomic DNA

C6065G
Clear

NRAS G12S Genomic DNA

C6066G
Clear

NRAS G13R Genomic DNA

C6069G
Clear

NRAS Q61K Genomic DNA

C6072G
Clear

NRAS Q61R Genomic DNA (c.182A>G)

C6071G
Clear

NRAS Q61R Genomic DNA (c.182A>T)

C6073G
Clear

PIK3CA C420R Genomic DNA

C6060G
Clear

PIK3CA E542K Genomic DNA

C6053G
Clear

PIK3CA E545G Genomic DNA

C6055G
Clear

PIK3CA E545K Genomic DNA

C6054G
Clear

PIK3CA G13V Genomic DNA

C6070G
Clear

PIK3CA H1047L Genomic DNA

C6052G
Clear

PIK3CA H1047R Genomic DNA

C6051G
Clear

PIK3CA Q546K Genomic DNA

C6057G
Clear

PTEN R130G Genomic DNA

C6127G
Clear

PTEN R130Q Genomic DNA

C6128G
Clear

PTEN R233* Genomic DNA

C6133G
Clear

RKO Genomic DNA (Wild Type)

C6051G-WT
Clear

TP53 C242Y Genomic DNA

C6086G
Clear

TP53 D281G Genomic DNA

C6101G
Clear

TP53 G245C Genomic DNA

C6090G
Clear

TP53 G245D Genomic DNA

C6088G
Clear

TP53 G245S Genomic DNA

C6087G
Clear

TP53 G245V Genomic DNA

C6089G
Clear

TP53 R158C Genomic DNA

C6193G
Clear

TP53 R158G Genomic DNA

C6194G
Clear

TP53 R248L Genomic DNA

C6093G
Clear

TP53 R248Q Genomic DNA

C6091G
Clear

TP53 R248W Genomic DNA

C6092G
Clear

TP53 R273C Genomic DNA

C6099G
Clear

TP53 R273H Genomic DNA

C6098G
Clear

TP53 R282G Genomic DNA

C6103G
Clear

TP53 R282Q Genomic DNA

C6104G
Clear