Optimize your FFPE Protocols Without Using Precious Clinical Samples

CrownBio now offers formalin-fixed, paraffin-embedded (FFPE) tissue block reference standards, which are ideal for optimizing your sample processing protocols for formalin-fixed specimens, without the need to use precious clinical samples.

Formalin fixation is commonly used for the preservation of biological specimens. While this process allows for the long-term storage of biological samples, it can lower the yields of extracted DNA, and cause chemical changes in nucleic acid structure – both of which can adversely affect downstream characterization. These FFPE reference standards allow you to optimize your sample processing protocols for formalin-fixed specimens, without the need to use precious clinical samples.

Product Name Catalog # Cosmic ID Details
BRAF V600D FFPE Block C4048B COSM477

Details

BRAF V600E FFPE Block (c.1799_1800TG>AA) C4046B COSM475

Details

BRAF V600E FFPE Block (c.1799T>A) C4047B COSM476

Details

BRAF V600G FFPE Block C4050B COSM6137

Details

BRAF V600K FFPE Block C4044B COSM473

Details

BRAF V600M FFPE Block C4049B COSM1130

Details

BRAF V600R FFPE Block C4045B COSM474

Details

EGFR V769_D770insASV FFPE Block C4026B COSM12376

Details

EGFR c.2310_2311insGGT p.D770_N771insG FFPE Block C4027B COSM12378

Details

EGFR c.2319_2320insCAC p.H773_V774insH FFPE Block C4028B 12377

Details

EGFR E746_A750>IP FFPE Block C4024B COSM13550

Details

EGFR E746_A750del FFPE Block (c.2235_2249del15) C4016B COSM6223

Details

EGFR E746_A750del FFPE Block (c.2236_2250del15) C4017B COSM6225

Details

EGFR E746_S752>A FFPE Block C4007B COSM12367

Details

EGFR E746_S752>D FFPE Block C4005B COSM6220

Details

EGFR E746_S752>V FFPE Block C4008B COSM12384

Details

EGFR E746_T751>A FFPE Block C4010B COSM12678

Details

EGFR E746_T751>I FFPE Block C4014B COSM13551

Details

EGFR E746_T751>V FFPE Block C4013B COSM12386

Details

EGFR E746_T751del FFPE Block C4009B COSM12728

Details

EGFR G719A FFPE Block C4002B COSM6239

Details

EGFR G719C FFPE Block C4001B COSM6253

Details

EGFR G719S FFPE Block C4000B COSM6252

Details

EGFR K745_E749del FFPE Block C4015B COSM26038

Details

EGFR L747_A750>P FFPE Block (c.2238_2248>GC) C4022B COSM12422

Details

EGFR L747_A750>P FFPE Block (c.2239_2248TTAAGAGAAG>C) C4021B COSM12382

Details

EGFR L747_E749del FFPE Block C4023B COSM6218

Details

EGFR L747_P753>Q FFPE Block C4006B COSM12387

Details

EGFR L747_P753>S FFPE Block C4004B COSM12370

Details

EGFR L747_S752del FFPE Block C4003B COSM6255

Details

EGFR L747_T751>P FFPE Block C4018B COSM12383

Details

EGFR L747_T751>Q FFPE Block C4020B COSM12419

Details

EGFR L747_T751>S FFPE Block C4019B COSM6210

Details

EGFR L747_T751del FFPE Block (c.2239_2253del15) C4011B COSM6254

Details

EGFR L747_T751del FFPE Block (c.2240_2254del15) C4012B COSM12369

Details

EGFR L858R FFPE Block C4030B COSM6224

Details

EGFR L861Q FFPE Block C4031B 6213

Details

EGFR S768I FFPE Block C4025B COSM6241

Details

EGFR T790M FFPE Block C4029B COSM6240

Details

HCT116 FFPE Block (Wild Type) C4052B-WT

Details

HRAS G13R FFPE Block C6078B 486

Details

HRAS Q61K FFPE Block C6079B 496

Details

HRAS Q61R FFPE Block C6080B 487

Details

KRAS G12A FFPE Block C4037B COSM522

Details

KRAS G12C FFPE Block C4032B COSM516

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KRAS G12D FFPE Block C4036B COSM521

Details

KRAS G12R FFPE Block C4034B COSM518

Details

KRAS G12S FFPE Block C4033B COSM517

Details

KRAS G12V FFPE Block C4035B COSM520

Details

KRAS G13A FFPE Block C4042B COSM533

Details

KRAS G13C FFPE Block C4038B COSM527

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KRAS G13D FFPE Block C4041B COSM532

Details

KRAS G13R FFPE Block C4040B COSM529

Details

KRAS G13S FFPE Block C4039B COSM528

Details

KRAS G13V FFPE Block C4043B COSM534

Details

KRAS Q61H FFPE Block C6062B 554

Details

NRAS E62fs*6 FFPE Block C6200B 5044298

Details

NRAS G12C FFPE Block C6067B 562

Details

NRAS G12D FFPE Block C6065B 564

Details

NRAS G12S FFPE Block C6066B 563

Details

NRAS G13R FFPE Block C6069B 569

Details

NRAS Q61K FFPE Block C6072B 580

Details

NRAS Q61R FFPE Block (c.182A>G) C6071B 584

Details

NRAS Q61R FFPE Block (c.182A>T) C6073B 583

Details

PIK3CA E542K FFPE Block C6053B 760

Details

PIK3CA E545G FFPE Block C6055B 764

Details

PIK3CA E545K FFPE Block C6054B 763

Details

PIK3CA H1047R FFPE Block C6051B 775

Details

PIK3CA Q546K FFPE Block C6057B 766

Details

RKO FFPE Block (Wild Type) C4051B-WT

Details

TP53 G245C FFPE Block C6090B 11081

Details

TP53 G245D FFPE Block C6088B 43606

Details

TP53 G245S FFPE Block C6087B 6932

Details

TP53 G245V FFPE Block C6089B 11196

Details

Related isogenic cell lines and additional reference standards, including cell pellets and genomic DNA are available too.

About the MAPK Pathway

The MAPK signaling pathway encompasses a series of signal transduction events that begin with the engagement of EGFR at the outer cell membrane, and proceed through KRAS, BRAF, MEK, and ERK. This signaling cascade ultimately results in transcriptional activation of key genes that promote cellular proliferation, survival, differentiation, motility, and angiogenesis. As such, the MAPK pathway is one of the most frequently activated pathways in cancer, and several drugs have pharmacogenomics profiles that depend upon the MAPK mutational status.

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